Welcome to The Jha Lab
Meet The Group
Principal Investigator
Group Members
Abhilasha Atul Doke
Senior Research Fellow
E-mail ID: aa.doke@ncl.res.in
I hold a Master's degree from Savitribai Phule Pune University. Currently I am aiming to investigate the influence of environmental conditions on the folding and aggregation energy landscape of TDP-43. My research interests span protein structures and animal behavior, and I'm intrigued by the cellular mechanisms of vision. Beyond academia, I thrive on exploring the world, and seeking the thrill of adventure sports.
Sonal Rajendra More
Senior Research Fellow
E-mail ID: sr.more@ncl.res.in
I have completed my master's from Shivaji University, Kolhapur in Environmental Biotechnology, and my bachelor's degree from K.T.H.M College, Nashik, in Biotechnology. I am working on site-specific studies of misfolding and aggregation of aggregation-prone protein, TDP-43 using fluorescence-based methods. I intend to understand the molecular basics of unfolding, misfolding, oligomerization, and aggregation. Apart from research, I love to spend time dancing and reading. I enjoy socializing.
Anjali Divakar Patil
Senior Research Fellow
E-mail ID: ad.patil@ncl.res.in
I have done my master's in Zoology from Shivaji University, Kolhapur. Currently, I am working on precursor conformations of protein TDP-43 involved in misfolding and aggregation; which is a pathology in Amyotrophic Lateral Sclerosis. I am also keen to see what will be the effect of disease-related mutations on the folding of the TDP-43 protein and its aggregation.
Apart from Science, stories excite me! So, I appreciate literature, movies, plays, and web series of different genres! And l feel the music is one of the best gift given by the nature!
Mona Sunil Kirmire
Senior Research Fellow
E-mail ID: ms.kirmire@ncl.res.in
I completed my post-graduation in Zoology (Molecular Biology) from Sant Gadge Baba Amravati University, Amravati. I am interested in understanding the role of RBM45 in misfolding and aggregation which is involved in Amyotrophic Lateral Sclerosis (ALS), it also shows co-aggregation with other ALS-involved proteins like TDP43 and FUS. Therefore, I am also studying the nature of co-aggregation of RBM45 with TDP43.
Besides Science, I love to play basketball. As the world has beautiful places, I love to explore them. Sometimes colours give me peace therefore I like to play with them on white paper.
Shruti Tiwari
Junior Research Fellow
E-mail ID: s.tiwari@ncl.res.in
I have completed my post-graduation in Biotechnology from Devi Ahilya Vishwavidyalaya, Indore. I am interested in investigation of biophysical properties and mechanism of aggregation of TDP-43 in neurodegenerative disease and the study of role of small molecule in modulating TDP-43 aggregation.
My hobbies are watching movies and web series, especially horror and comedy. I am a foodie, with passion for tasting and enjoying delightful meals.
Priyanka Jena
Junior Research Fellow
E-mail ID: p.jena@ncl.res.in
I pursued my M.Sc. with a specialization in Biotechnology from G.I.E.T University, Odisha and My research focuses on studying "Full-Length TDP-43: Environmental Variability and Its Impact on Structural Integrity’’ & also showing interests in investigating site-specific conformational changes during the misfolding and aggregation of the nucleic acid-binding domain of TDP-43 using multi-site FRET.
In addition to my scientific interests, I enjoy dancing, painting, and making crafts, which allow me to explore my creative side.
Ananda Duary
Junior Research Fellow
E-mail ID: a.duary@ncl.res.in
I hold a Master’s degree in Human Physiology from the University of Calcutta and currently serve as a Junior Research Fellow. My research focuses on protein folding and aggregation studies of the TDP-43 protein, which plays a critical role in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Through my work, I aim to contribute to a deeper understanding of these diseases and potentially pave the way for therapeutic advancements.
Beyond the lab, I am passionate about music and traveling, which provide me with inspiration in my life.
Deepak Jadhav
Junior Research Fellow
E-mail ID: dr.jadhav@ncl.res.in
I have completed my Master’s in Zoology from Savitribai Phule, Pune. Currently, I am focusing on the tau protein, a key component in Alzheimer’s disease and related neurodegenerative disorders. My research investigates protein folding, misfolding, and aggregation kinetics using advanced biophysical approaches, with the goal of understanding disease mechanisms and developing potential therapeutic solutions.